Interaction between the components of the interferon gamma receptor complex.
AuthorsSerguei V. Kotenko , Lara S. Izotova , Brian P. Pollack , Thomas M. Mariano , Robert J. Donnelly , Geetha Muthukumaran , Jeffry R. Cook , Gianni Garotta, Olli Silvennoinen, James N. Ihle, Sidney Pestka
JournalJ Biol Chem
PubMed ID7673114
'Interferon gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different chains: the IFN-gamma receptor binding subunit (IFN-gamma R, IFN-gamma R1), and a transmembrane accessory factor (AF-1, IFN-gamma R2) necessary for signal transduction. Using cell lines expressing different cloned components of the IFN-gamma receptor complex, we examined the ... More
Effects of hypoxia, glucose deprivation and recovery on the expression of nucleoside transporters and adenosine uptake in primary culture of rat cortical astrocytes.
AuthorsRedzic ZB, Malatiali SA, Al-Bader M, Al-Sarraf H
JournalNeurochem Res
PubMed ID20577800
'The aim of this study was to explore effects of hypoxia, glucose deprivation (HGD) and recovery on expression and activities of equilibrative nucleoside transporters (rENT) and concentrative nucleoside transporters (rCNT) in rat astrocytes in primary culture. Amounts of cellular ATP in the control group (CG, 5% CO(2) in air, medium ... More