Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells.
Authors Tang Shaohua; Bhatia Bobby; Maldonado Carlos J; Yang Peiying; Newman Robert A; Liu Junwei; Chandra Dhyan; Traag Jeanine; Klein Russell D; Fischer Susan M; Chopra Dharam; Shen Jianjun; Zhau Haiyen E; Chung Leland W K; Tang Dean G;
JournalJ Biol Chem
PubMed ID11839751
'15-Lipoxygenase 2 (15-LOX2) is a recently cloned human lipoxygenase that shows tissue-restricted expression in prostate, lung, skin, and cornea. The protein level and enzymatic activity of 15-LOX2 have been shown to be down-regulated in prostate cancers compared with normal and benign prostate tissues. The biological function of 15-LOX2 and the ... More
Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice.
We found that the second intron of Stat5a was one of the common integration sites of the endogenous ecotropic murine leukemia virus, i.e., SL/Kh virus integration-1 (Svi1), in early pre-B lymphomas in SL/Kh mice. The high expression of STAT5A induced by Svi1 integration and activation accelerated the transcription of its ... More
Identification of genes downstream of Pax6 in the mouse lens using cDNA microarrays.
Pax6 is a transcription factor that regulates the development of the visual, olfactory, and central nervous systems, pituitary, and pancreas. Pax6 is required for induction, growth, and maintenance of the lens; however, few direct Pax6 target genes are known. This study was designed to identify batteries of differentially expressed genes ... More
Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans.
Authors Hashmi Sarwar; Britton Collette; Liu Jing; Guiliano David B; Oksov Yelena; Lustigman Sara;
JournalJ Biol Chem
PubMed ID11707440
Cysteine proteases play critical biological roles in both intracellular and extracellular processes. We characterized Ce-cpl-1, a Caenorhabditis elegans cathepsin L-like cysteine protease. RNA interference with Ce-cpl-1 activity resulted in embryonic lethality and a transient delayed growth of larvae to egg producing adults, suggesting an essential role for cpl-1 during embryogenesis, ... More