The frpB1 gene of Helicobacter pylori is regulated by iron and encodes a membrane protein capable of binding haem and haemoglobin.
AuthorsCarrizo-Chávez MA, Cruz-Castañeda A, Olivares-Trejo Jde J,
JournalFEBS Lett
PubMed ID22449974
'FrpB1 is a novel membrane protein of Helicobacter pylori that is capable of binding both haem and haemoglobin but consistently shows more affinity for haem. The mRNA levels of frpB1 were repressed by iron and lightly modulated by haem or haemoglobin. The overexpression of the frpB1 gene supported cellular growth ... More
Transferrin regulates mRNA levels of a gene involved in iron utilization in Entamoeba histolytica.
AuthorsSánchez-Cruz C, López-Casamichana M, Cruz-Castañeda A, de Jesús Olivares-Trejo J,
JournalMol Biol Rep
PubMed ID21947947
Entamoeba histolytica is a human pathogen, which can survive using haemoglobin (Hb) as only iron supply. Two probable haemophores (Ehhmbp26 and Ehhmbp45) are involved in iron acquisition in this parasite. However, mechanisms related to their transcriptional regulation have not been studied yet. In the present work, transcriptional profiles of both ... More