CD22 and Siglec-G: B-cell inhibitory receptors with distinct functions.
AuthorsNitschke L
JournalImmunol Rev
PubMed ID19594633
'Siglecs (sialic acid-binding immunoglobulin-like lectins) are sialic acid-binding proteins, which are expressed on many cell types of the immune system. B cells express two members of the Siglec family, CD22 (Siglec-2) and Siglec-G, both of which have been shown to inhibit B-cell signaling. CD22 recruits the tyrosine phosphatase Src homology ... More
CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction.
AuthorsTedder TF, Poe JC, Haas KM
JournalAdv Immunol
PubMed ID16227086
'Recent advances in the study of CD22 indicate a complex role for this transmembrane glycoprotein member of the immunoglobulin superfamily in the regulation of B lymphocyte survival and proliferation. CD22 has been previously recognized as a potential lectin-like adhesion molecule that binds alpha2,6-linked sialic acid-bearing ligands and as an important ... More
CD22: an inhibitory enigma.
AuthorsWalker JA, Smith KG
JournalImmunology
PubMed ID18067554
'CD22 is an inhibitory coreceptor of the B-cell receptor (BCR), and plays a critical role in establishing signalling thresholds for B-cell activation. Like other coreceptors, the ability of CD22 to modulate B-cell signalling is critically dependent upon its proximity to the BCR, and this in turn is governed by the ... More
CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor.
AuthorsSato S, Tuscano JM, Inaoki M, Tedder TF
JournalSemin Immunol
PubMed ID9695185
The CD22 cell-surface adhesion molecule is capable of modulating B lymphocyte antigen receptor (BCR)-mediated signals, as well as the generation of BCR-independent signals. Within the cytoplasmic domain of CD22 are motifs that are structurally homologous to known activation and inhibitory motifs. These motifs demonstrate physiologic significance via associations with known ... More
B cell signaling and autoimmune diseases: CD19/CD22 loop as a B cell signaling device to regulate the balance of autoimmunity.
AuthorsFujimoto M, Sato S
JournalJ Dermatol Sci
PubMed ID17223015
Autoimmune diseases, including connective tissue diseases and bullous diseases, may be life-threatening. Recent clinical and experimental approaches have demonstrated that B cells play critical roles in the manifestation of autoimmune disease not only by well-established autoantibody-mediated mechanisms but also by a variety of other functions. These B cell functions are ... More