Coupling of glucose deprivation with impaired histone H2B monoubiquitination in tumors.
AuthorsUrasaki Y, Heath L, Xu CW
JournalPLoS One
PubMed ID22615809
Metabolic reprogramming is associated with tumorigenesis. However, glucose metabolism in tumors is poorly understood. Here, we report that glucose levels are significantly lower in bulk tumor specimens than those in normal tissues of the same tissue origins. We show that mono-ubiquitinated histone H2B (uH2B) is a semi-quantitative histone marker for ... More
The role of p53 deacetylation in p21Waf1 regulation by laminar flow.
AuthorsZeng L, Zhang Y, Chien S, Liu X, Shyy JY,
JournalJ Biol Chem
PubMed ID12716906
Laminar flow arrests vascular endothelial cells at the G0/G1 phase with concurrent increase in p53 and p21Waf1. We investigated the molecular mechanism by which laminar flow activates p53 and p21Waf1 in endothelial cells. The application of a laminar flow (12 dyn/cm2) increased the deacetylation at Lys-320 and Lys-373 of p53 ... More
Glucose uptake mediated by glucose transporter 1 is essential for early tooth morphogenesis and size determination of murine molars.
AuthorsIda-Yonemochi H, Nakatomi M, Harada H, Takata H, Baba O, Ohshima H
JournalDev Biol
PubMed ID22226978
Glucose is an essential source of energy for body metabolism and is transported into cells by glucose transporters (GLUTs). Well-characterized class I GLUT is subdivided into GLUTs1-4, which are selectively expressed depending on tissue glucose requirements. However, there is no available data on the role of GLUTs during tooth development. ... More