The role of p53 deacetylation in p21Waf1 regulation by laminar flow.
AuthorsZeng L, Zhang Y, Chien S, Liu X, Shyy JY,
JournalJ Biol Chem
PubMed ID12716906
Laminar flow arrests vascular endothelial cells at the G0/G1 phase with concurrent increase in p53 and p21Waf1. We investigated the molecular mechanism by which laminar flow activates p53 and p21Waf1 in endothelial cells. The application of a laminar flow (12 dyn/cm2) increased the deacetylation at Lys-320 and Lys-373 of p53 ... More