Stable production of a human growth hormone antagonist from CHO cells adapted to serum-free suspension culture.
Authors Haldankar R; Kopchick J J; Ridgway D;
JournalBiotechnol Prog
PubMed ID10356250
Human growth hormone (hGH) is a polypeptide with 191 amino acids and a molecular mass of 22 kDa. An hGH analogue was created with a single amino acid substitution (glycine[G] 120 to arginine[R]) in the third alpha-helix of the hGH molecule. This hGH analogue, named hGHG120R, was found to be ... More