A role for the cell adhesion molecule CD44 and sulfation in leukocyte-endothelial cell adhesion during an inflammatory response?
AuthorsJohnson P, Maiti A, Brown KL, Li R
JournalBiochem Pharmacol
PubMed ID10660111
'CD44 is a widely expressed cell adhesion molecule that has been implicated in a variety of biological processes including lymphopoiesis, angiogenesis, wound healing, leukocyte extravasation at inflammatory sites, and tumor metastasis. The adhesive function of CD44, like other molecules involved in inducible adhesion, is tightly regulated. Post-translational modifications, isoform expression, ... More
[The role of CD44 in pathogenesis of atherosclerosis].
AuthorsProtasiewicz J, Adamiec R
JournalPol Merkur Lekarski
PubMed ID16379326
'The pathogenesis of atherosclerosis, which remains the most important reason of mortality, is not well understood. Its present conception includes recruitment of inflammatory cells to the vessel wall, activation of vascular smooth muscle cells and endothelium. Much evidence indicate that CD44 molecule, the main receptor for hyaluronan, takes part in ... More
CD44 and its partners in metastasis.
AuthorsJothy S
JournalClin Exp Metastasis
PubMed ID12741678
The establishment of metastasis requires that tumor cells acquire new adhesion and migration properties to emigrate from primary sites and colonize distant organs. CD44 is a cell membrane protein often overexpressed on tumor cells and, being both a cell-cell and cell-extracellular matrix adhesion protein, is well positioned to contribute to ... More
Roles of CD44 in chemical-induced liver injury.
AuthorsKimura K, Hayashi S, Nagaki M
JournalCurr Opin Drug Discov Devel
PubMed ID20047150
CD44 has been identified as one of the adhesion molecules that regulate cell migration in inflamed tissue. The principal ligand of CD44 is hyaluronan, and CD44 is involved in the metabolism of this compound. Furthermore, an increasing quantity of evidence suggests that CD44 has various functions related to inflammatory disease. ... More
CD44 - a new cardiovascular drug target or merely an innocent bystander?
AuthorsKrettek A, Sjöberg S
JournalCardiovasc Hematol Disord Drug Targets
PubMed ID20044914
CD44, short for cluster of differentiation 44, is an adhesion molecule of the hyaluronate receptor family. Expressed on the surface of most vertebrate cells, it functions as a receptor for several extracellular matrix components, e.g., hyaluronan, collagen, laminin, fibronectin, and osteopontin. CD44 has in recent years been intensively studied in ... More