Identification of the KAI1 metastasis suppressor gene as a hypoxia target gene.
AuthorsKim B, Boo K, Lee JS, Kim KI, Kim WH, Cho HJ, Park YB, Kim HS, Baek SH
JournalBiochem Biophys Res Commun
PubMed ID20123085
'KAI1 is a metastasis suppressor gene known to inhibit cancer metastasis without affecting primary tumorigenicity. Although KAI1 expression has been reported to undergo transcriptional regulation, how its expression is up- or down-regulated by specific upstream signaling pathways has not been studied in detail. In this study, we characterized the regulatory ... More
KAI1/CD82, a tumor metastasis suppressor.
AuthorsLiu WM, Zhang XA
JournalCancer Lett
PubMed ID16260083
Tetraspanin KAI1/CD82 is a wide-spectrum tumor metastasis suppressor. KAI1/CD82 suppresses tumor metastasis by primarily inhibiting cancer cell motility and invasiveness. In tetraspanin-enriched microdomain, KAI1/CD82 associates with the proteins important for cell migration such as cell adhesion molecule, growth factor receptor, and signaling molecule. Likely, KAI1/CD82 down-regulates the functions of these ... More
CD82 metastasis suppressor gene: a potential target for new therapeutics?
AuthorsTonoli H, Barrett JC
JournalTrends Mol Med
PubMed ID16271511
The transmembrane glycoprotein CD82 is a member of the tetraspanin protein family and is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion and migration to apoptosis and cell-morphology alterations. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the ... More
Correlations between reduced expression of the metastasis suppressor gene KAI-1 and accumulation of p53 in uterine carcinomas and sarcomas.
AuthorsBriese J, Schulte HM, Sajin M, Bamberger C, Redlin K, Milde-Langosch K, Löning T, Bamberger AM
JournalVirchows Arch
PubMed ID18415123
Kangai (KAI)-1 (CD82) is a metastasis suppressor gene, which belongs to the family of tetraspanin proteins. A loss of KAI-1 expression is associated with the advanced stages of many human malignancies. The present study was designed to investigate the expression pattern of KAI-1 in the normal endometrium and uterine tumors ... More