Evidence that the transmembrane biogenesis of aquaporin 1 is cotranslational in intact mammalian cells.
Authors Dohke Yoko; Turner R James;
JournalJ Biol Chem
PubMed ID11884383
Most polytopic membrane proteins are believed to integrate into the membrane of the endoplasmic reticulum (ER) cotranslationally. However, recent studies with Xenopus oocytes and dog pancreatic microsomes have suggested that this is not the case for human aquaporin 1 (AQP1). These experiments indicate that membrane-spanning segments (MSSs) 2 and 4 ... More