TNF-related activation-induced cytokine (TRANCE) induces angiogenesis through the activation of Src and phospholipase C (PLC) in human endothelial cells.
Authors: Kim Young-Mi; Kim Young-Myoung; Lee You Mie; Kim Hae-Sun; Kim Jong Dai; Choi Yongwon; Kim Kyu-Won; Lee Soo-Young; Kwon Young-Guen;
Journal:J Biol Chem
PubMed ID:11741951
Angiogenesis is an essential step for many physiological and pathological processes. Tumor necrosis factor (TNF) superfamily cytokines are increasingly recognized as key modulators of angiogenesis. In this study, we tested whether TNF-related activation-induced cytokine (TRANCE), a new member of the TNF superfamily, possesses angiogenic activity in vitro and in vivo. ... More