PAX6 gene is activated by the basic helix-loop-helix transcription factor NeuroD/BETA2.
AuthorsMarsich E, Vetere A, Di Piazza M, Tell G, Paoletti S,
JournalBiochem J
PubMed ID12962539
'PAX6 is a transcription factor that plays an important role during pancreas morphogenesis. The aim of this study is to identify the upstream activator(s) of the PAX6 gene possibly involved in the early stage of pancreas differentiation. Recently, individual elements regulating the PAX6 gene activity in the pancreas have been ... More
Genetic analysis of the herpes simplex virus type 1 UL20 protein domains involved in cytoplasmic virion envelopment and virus-induced cell fusion.
AuthorsMelancon JM, Foster TP, Kousoulas KG,
JournalJ Virol
PubMed ID15220406
'The herpes simplex virus type 1 UL20 protein (UL20p) is an important determinant for cytoplasmic virion morphogenesis and virus-induced cell fusion. To delineate the functional domains of the UL20 protein, we generated a panel of single and multiple (cluster) alanine substitutions as well as UL20p carboxyl-terminal truncations. The UL20 mutant ... More
Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI.
AuthorsZakowicz H, Yang HS, Stark C, Wlodawer A, Laronde-Leblanc N, Colburn NH,
JournalRNA
PubMed ID15661843
Eukaryotic initiation factor (eIF) 4A unwinds secondary and tertiary structures in the 5'-untranslated region of mRNA, permitting translation initiation. Programmed cell death 4 (Pdcd4) is a novel transformation suppressor and eIF4A-binding partner that inhibits eIF4A helicase activity and translation. To elucidate the regions of eIF4A that are functionally significant in ... More