Generation, isolation, and engraftment of in vitro-derived human T cell progenitors.
AuthorsAwong G, Zúñiga-Pflücker JC
JournalMethods Mol Biol
PubMed ID23179828
T cells typically differentiate via a series of coordinated steps within the highly specialized microenvironment of the thymus. Traditionally, human T-lymphopoiesis in vitro has been studied using the hybrid human/mouse fetal thymic organ culture system. Pioneering work by McCune et al. devised a method to examine human T cell development ... More