S100P promotes pancreatic cancer growth, survival, and invasion.
AuthorsArumugam T, Simeone DM, Van Golen K, Logsdon CD
JournalClin Cancer Res
PubMed ID16061848
In the current study, we examined the functional significance and mechanism of action of S100P in pancreatic cancer cells.
S100P is a novel interaction partner and regulator of IQGAP1.
AuthorsHeil A, Nazmi AR, Koltzscher M, Poeter M, Austermann J, Assard N, Baudier J, Kaibuchi K, Gerke V
JournalJ Biol Chem
PubMed ID21177863
Ca(2+)-binding proteins of the S100 family participate in intracellular Ca(2+) signaling by binding to and regulating specific cellular targets in their Ca(2+)-loaded conformation. Because the information on specific cellular targets of different S100 proteins is still limited, we developed an affinity approach that selects for protein targets only binding to ... More
Functional evidence implicating S100P in prostate cancer progression.
AuthorsBasu GD, Azorsa DO, Kiefer JA, Rojas AM, Tuzmen S, Barrett MT, Trent JM, Kallioniemi O, Mousses S
JournalInt J Cancer
PubMed ID18452169
S100P protein regulates calcium signal transduction and mediates cytoskeletal interaction, protein phosphorylation and transcriptional control. We have previously shown how elevated S100P levels in prostate cancer strongly correlate with progression to metastatic disease. In our study, we evaluated the functional significance of S100P expression on prostate tumor growth in vitro ... More
Molecular regulation of S100P in human lung adenocarcinomas.
AuthorsRehbein G, Simm A, Hofmann HS, Silber RE, Bartling B
JournalInt J Mol Med
PubMed ID18575778
Lung adenocarcinoma is characterised by an upregulation of S100P, which mediates its function intracellularly but also extracellularly. Recent studies suggest that extracellular S100P contributes to tumour development following interaction with the receptor for advanced glycation end-products (RAGE). As RAGE is highly downregulated in lung cancer, one might speculate that S100P ... More