Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression.
AuthorsZelko IN, Mariani TJ, Folz RJ
JournalFree Radic Biol Med
PubMed ID12126755
'Superoxide dismutases are an ubiquitous family of enzymes that function to efficiently catalyze the dismutation of superoxide anions. Three unique and highly compartmentalized mammalian superoxide dismutases have been biochemically and molecularly characterized to date. SOD1, or CuZn-SOD (EC 1.15.1.1), was the first enzyme to be characterized and is a copper ... More
Activation of superoxide dismutases: putting the metal to the pedal.
AuthorsCulotta VC, Yang M, O'Halloran TV
JournalBiochim Biophys Acta
PubMed ID16828895
'Superoxide dismutases (SOD) are important anti-oxidant enzymes that guard against superoxide toxicity. Various SOD enzymes have been characterized that employ either a copper, manganese, iron or nickel co-factor to carry out the disproportionation of superoxide. This review focuses on the copper and manganese forms, with particular emphasis on how the ... More
No association between SOD2 Val16Ala polymorphism and breast cancer susceptibility: a meta-analysis based on 9,710 cases and 11,041 controls.
AuthorsMa X, Chen C, Xiong H, Fan J, Li Y, Lin H, Xu R, Huang G, Xu B
JournalBreast Cancer Res Treat
PubMed ID20052533
Breast cancer is the most common cancer in women worldwide, but its etiology is still unclear. It is believed that oxidative stress plays an essential role in the development of breast cancer, while SOD2 is one of the primary enzymes that directly convert potential harmful oxidizing species to harmless metabolites. ... More