Tetranectin Binds to the Kringle 1-4 Form of Angiostatin and Modifies Its Functional Activity.
AuthorsMogues T, Etzerodt M, Hall C, Engelich G, Graversen JH, Hartshorn KL
JournalJ Biomed Biotechnol
PubMed ID15240916
'Tetranectin is a plasminogen kringle 4 domain-binding protein present in plasma and various tissue locations. Decreased plasma tetranectin or increased tetranectin in stroma of cancers correlates with cancer progression and adverse prognosis. A possible mechanism through which tetranectin could influence cancer progression is by altering activities of plasminogen or the ... More
Identification of tetranectin as a potential biomarker for metastatic oral cancer.
AuthorsArellano-Garcia ME, Li R, Liu X, Xie Y, Yan X, Loo JA, Hu S
JournalInt J Mol Sci
PubMed ID20957082
'Lymph node involvement is the most important predictor of survival rates in patients with oral squamous cell carcinoma (OSCC). A biomarker that can indicate lymph node metastasis would be valuable to classify patients with OSCC for optimal treatment. In this study, we have performed a serum proteomic analysis of OSCC ... More
Mice with a targeted deletion of the tetranectin gene exhibit a spinal deformity.
AuthorsIba K, Durkin ME, Johnsen L, Hunziker E, Damgaard-Pedersen K, Zhang H, Engvall E, Albrechtsen R, Wewer UM
JournalMol Cell Biol
PubMed ID11604516
'Tetranectin is a plasminogen-binding, homotrimeric protein belonging to the C-type lectin family of proteins. Tetranectin has been suggested to play a role in tissue remodeling, due to its ability to stimulate plasminogen activation and its expression in developing tissues such as developing bone and muscle. To test the functional role ... More
Impaired cutaneous wound healing in mice lacking tetranectin.
AuthorsIba K, Hatakeyama N, Kojima T, Murata M, Matsumura T, Wewer UM, Wada T, Sawada N, Yamashita T
JournalWound Repair Regen
PubMed ID19152657
'Tetranectin was originally purified from human serum on the basis of plasminogen kringle 4-binding properties. Tetranectin enhances plasminogen activation by a tissue-type plasminogen activator so that it has been suggested to play a role in tissue remodeling. We have generated mice with a targeted disruption of the tetranectin gene to ... More
The heparin-binding site in tetranectin is located in the N-terminal region and binding does not involve the carbohydrate recognition domain.
AuthorsLorentsen RH, Graversen JH, Caterer NR, Thogersen HC, Etzerodt M
JournalBiochem J
PubMed ID10727405
'Tetranectin is a homotrimeric plasma and extracellular-matrix protein that binds plasminogen and complex sulphated polysaccharides including heparin. In terms of primary and tertiary structure, tetranectin is related to the collectin family of Ca(2+)-binding C-type lectins. Tetranectin is encoded in three exons. Exon 3 encodes the carbohydrate recognition domain, which binds ... More
Tetranectin in cerebrospinal fluid of patients with multiple sclerosis.
AuthorsStoevring B, Jaliashvili I, Thougaard AV, Ensinger C, Høgdall CK, Rasmussen LS, Sellebjerg F, Christiansen M
JournalScand J Clin Lab Invest
PubMed ID17101549
Tetranectin (TN) is a glycoprotein and C-type lectin thought to play a prominent role in tissue remodelling. The aim of this study was to determine the TN serum and cerebrospinal fluid (CSF) concentration in patients with multiple sclerosis (MS) and controls. ... More