Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors.
AuthorsSharma A, Trivedi NR, Zimmerman MA, Tuveson DA, Smith CD, Robertson GP,
JournalCancer Res
PubMed ID15781657
Activating mutations of the B-RAF gene are observed in >60% of human melanomas. Approximately 90% of these mutations occur in the activation segment of the kinase domain as a single-base substitution that converts a valine to glutamic acid at codon 599 (V599E) in exon 15. This mutation causes activation of ... More