Tpl2 phosphorylation at Thr290 is induced by LPS via an IKKbeta -dependent pathway and is required for Tpl2 activation by external signals.
AuthorsCho J, Melnick M, Solidakis GP, Tsichlis PN,
JournalJ Biol Chem
PubMed ID15778223
'The serine-threonine protein kinase encoded by the Tpl2 proto-oncogene transduces Toll like receptor and death receptor signals in a variety of cell types. Here we show that Tpl2 undergoes phosphorylation at Thr290 both in cells overexpressing Tpl2, as well as in cells stimulated with LPS or TNF-alpha, and that phosphorylation ... More