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Invitrogen

Amyloid Precursor Protein Monoclonal Antibody (LN27)

高级验证
48个已发表图片
82 篇参考文献
查看其他35个Amyloid Precursor Protein抗体

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产品信息

13-0200

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:250
查看28篇已发表文章 28篇已发表文章

免疫组化 (IHC)

5-10 µg/mL
查看14篇已发表文章 14篇已发表文章

免疫组化（石蜡） (IHC (P))

-
查看6篇已发表文章 6篇已发表文章

免疫细胞化学 (ICC/IF)

-
查看11篇已发表文章 11篇已发表文章

酶联免疫吸附实验 (ELISA)

0.1-0.5 µg/mL
查看4篇已发表文章 4篇已发表文章

免疫沉淀 (IP)

-
查看4篇已发表文章 4篇已发表文章

其他PubMed (Misc)

-
查看15篇已发表文章 15篇已发表文章
产品规格

种属反应

Human

已发表种属

Hamster, Human, Mouse, Non-human primate, Rabbit

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

LN27

抗原

Rec-beta-amyloid precursor protein (beta-APP 695)

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

purified

保存液

PBS

内含物

0.1% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2532993

靶标信息

Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. APP is important for neurite growth, neuronal adhesion and axonogenesis. APP is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing. Proteolytic cleavage of APP by beta- and gamma-secretases results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimer's disease. Abnormal regulation and processing of APP also plays a role in Down's syndrome, early onset familial Alzheimer's disease, and cerebral hemorrhage.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: ABPP; Alzheimer disease amyloid A4 protein homolog; Alzheimer disease amyloid protein; Amyloid b precursor protein; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid beta precursor protein (ABPP); amyloid beta protein; amyloid beta-protein precursor; Amyloid precursor protein; amyloid protein; Amyloid β precursor protein; Amyloid-beta (A4) precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; APP; APPI; beta-amyloid A4; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; Cerebral vascular amyloid peptide; CVAP; Pan-Abeta; peptidase nexin-II; PN-II; PreA4; Protease nexin-II; testicular tissue protein Li 2; unnamed protein product

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基因别名: A4; AAA; ABETA; ABPP; AD1; alpha-sAPP; APP; APPI; CTFgamma; CVAP; PN-II; PN2; preA4

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UniProt ID: (Human) B2R5V1

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Entrez Gene ID: (Human) 351

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功能
G-protein coupled receptor binding DNA binding chromatin binding serine-type endopeptidase inhibitor activity receptor binding frizzled binding insulin receptor binding integrin binding protein binding heparin binding peptidase activator activity enzyme binding peptidase inhibitor activity receptor activator activity acetylcholine receptor activator activity acetylcholine receptor binding apolipoprotein binding chemoattractant activity identical protein binding protein homodimerization activity heparan sulfate proteoglycan binding metal ion binding ephrin receptor binding transition metal ion binding protein heterodimerization activity receptor agonist activity low-density lipoprotein particle receptor binding RAGE receptor binding chaperone binding PTB domain binding growth factor receptor binding amylin binding protein serine/threonine kinase binding molecular function activator activity heparan sulfate binding
参与通路
negative regulation of transcription from RNA polymerase II promoter microglial cell activation response to yeast astrocyte activation involved in immune response regulation of transcription from RNA polymerase II promoter regulation of translation cellular copper ion homeostasis endocytosis apoptotic process cell adhesion G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Notch signaling pathway chemical synaptic transmission axonogenesis central nervous system development learning or memory learning memory mating behavior locomotory behavior axo-dendritic transport negative regulation of cell proliferation associative learning adult locomotory behavior visual learning response to lead ion regulation of gene expression positive regulation of macromolecule metabolic process positive regulation of gene expression negative regulation of gene expression response to auditory stimulus microglia development axon midline choice point recognition neuron remodeling dendrite development calcium-mediated signaling antibacterial humoral response antifungal humoral response regulation of Wnt signaling pathway extracellular matrix organization neuron projection development phospholipase D-activating G-protein coupled receptor signaling pathway positive regulation of chemokine production positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of superoxide anion generation regulation of toll-like receptor signaling pathway ionotropic glutamate receptor signaling pathway regulation of multicellular organism growth lipoprotein metabolic process positive regulation of apoptotic process positive regulation of MAPK cascade positive regulation of neuron apoptotic process innate immune response positive regulation of nitric oxide biosynthetic process positive regulation of neuron differentiation positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of Toll signaling pathway positive regulation of glycolytic process positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade astrocyte activation regulation of long-term neuronal synaptic plasticity collateral sprouting in absence of injury positive regulation of inflammatory response regulation of synapse structure or activity synapse organization defense response to Gram-negative bacterium defense response to Gram-positive bacterium positive regulation of calcium-mediated signaling positive regulation of cell activation cognition positive chemotaxis positive regulation of membrane protein ectodomain proteolysis regulation of protein metabolic process positive regulation of protein metabolic process protein homooligomerization protein tetramerization regulation of neurotransmitter uptake positive regulation of protein kinase B signaling low-density lipoprotein particle mediated signaling antimicrobial humoral immune response mediated by antimicrobial peptide protein trimerization positive regulation of ERK1 and ERK2 cascade response to interleukin-1 cellular response to copper ion cellular response to manganese ion cellular response to cAMP cellular response to norepinephrine stimulus positive regulation of monocyte chemotaxis negative regulation of canonical Wnt signaling pathway modulation of excitatory postsynaptic potential NMDA selective glutamate receptor signaling pathway positive regulation of gene expression, epigenetic positive regulation of cAMP/PKA signal transduction regulation of spontaneous synaptic transmission negative regulation of protein localization to nucleus regulation of beta-amyloid clearance negative regulation of long-term synaptic potentiation positive regulation of long-term synaptic potentiation positive regulation of NIK/NF-kappaB signaling regulation of calcium ion transmembrane transport via high voltage-gated calcium channel negative regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of dendritic spine maintenance positive regulation of amyloid precursor protein catabolic process regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of blood circulation positive regulation of G protein-coupled receptor internalization positive regulation of endothelin production positive regulation of protein import cellular response to beta-amyloid regulation of presynapse assembly positive regulation of response to endoplasmic reticulum stress regulation of amyloid fibril formation positive regulation of amyloid fibril formation regulation of response to calcium ion amyloid fibril formation cellular response to nerve growth factor stimulus neuron projection maintenance positive regulation of T cell migration positive regulation of excitatory postsynaptic potential positive regulation of extrinsic apoptotic signaling pathway
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