Multiple actions of neurturin correlate with spatiotemporal patterns of Ret expression in developing chick cranial ganglion neurons.
AuthorsHashino E, Johnson EM, Milbrandt J, Shero M, Salvi RJ, Cohan CS,
JournalJ Neurosci
PubMed ID10493748
'The neurotrophic effects of neurturin (NRTN) on chick cranial ganglia were evaluated at various embryonic stages in vitro and related to its receptor expression. NRTN promoted the outgrowth and survival of ciliary ganglion neurons at early embryonic (E) stages (E6-E12), trigeminal ganglion neurons at midstages (E9-E16), and vestibular ganglion neurons ... More
Motoneuronal Sema3C is essential for setting stereotyped motor tract positioning in limb-derived chemotropic semaphorins.
AuthorsSanyas I, Bozon M, Moret F, Castellani V,
JournalDevelopment
PubMed ID22899844
'The wiring of neuronal circuits requires complex mechanisms to guide axon subsets to their specific target with high precision. To overcome the limited number of guidance cues, modulation of axon responsiveness is crucial for specifying accurate trajectories. We report here a novel mechanism by which ligand/receptor co-expression in neurons modulates ... More
Metalloproteases and guidance of retinal axons in the developing visual system.
AuthorsWebber CA, Hocking JC, Yong VW, Stange CL, McFarlane S,
JournalJ Neurosci
PubMed ID12223563
'Axonal growth cones read cues in their environment that guide them to their target. Metalloproteases have been implicated in vitro in modulating the interaction of these cues with receptors in the growth cone. To determine whether metalloprotease function is important in the guidance of vertebrate axons in vivo, we applied ... More
A critical role for sonic hedgehog signaling in the early expansion of the developing brain.
AuthorsBritto J, Tannahill D, Keynes R,
JournalNat Neurosci
PubMed ID11788837
'The mechanisms that coordinate the three-dimensional shape of the vertebrate brain during development are largely unknown. We have found that sonic hedgehog (Shh) is crucial in driving the rapid, extensive expansion of the early vesicles of the developing midbrain and forebrain. Transient displacement of the notochord from the midbrain floor ... More
Differential effects of unnatural sialic acids on the polysialylation of the neural cell adhesion molecule and neuronal behavior.
AuthorsCharter NW, Mahal LK, Koshland DE, Bertozzi CR,
JournalJ Biol Chem
PubMed ID11786551
'In this study we have examined how unnatural sialic acids can alter polysialic acid expression and influence the adhesive properties of the neural cell adhesion molecule (NCAM). Unnatural sialic acids are generated by metabolic conversion of synthetic N-acyl mannosamines and are typically incorporated into cell-surface glycoconjugates. However, N-butanoylmannosamine and N-pentanoylmannosamine ... More
Ectopic Mitf in the embryonic chick retina by co-transfection of ß-catenin and Otx2.
AuthorsWestenskow PD, McKean JB, Kubo F, Nakagawa S, Fuhrmann S
JournalInvest Ophthalmol Vis Sci
PubMed ID20463321
Development of the retinal pigment epithelium (RPE) is controlled by intrinsic and extrinsic regulators including orthodenticle homeobox 2 (Otx2) and the Wnt/ß-catenin pathway, respectively. Otx2 and ß-catenin are necessary for the expression of the RPE key regulator microphthalmia-associated transcription factor (Mitf); however, neither factor is sufficient to promote Mitf expression ... More
Homeotic transformation of rhombomere identity after localized Hoxb1 misexpression.
AuthorsBell E, Wingate RJ, Lumsden A
JournalScience
PubMed ID10381880
Segmentation of the hindbrain and branchial region is a conserved feature of head development, involving the nested expression of Hox genes. Although it is presumed that vertebrate Hox genes function as segment identifiers, responsible for mediating registration between elements of diverse embryonic origin, this assumption has remained untested. To assess ... More
Cranial neural crest cells form corridors prefiguring sensory neuroblast migration.
AuthorsFreter S, Fleenor SJ, Freter R, Liu KJ, Begbie J,
Journal
PubMed ID23942515
The majority of cranial sensory neurons originate in placodes in the surface ectoderm, migrating to form ganglia that connect to the central nervous system (CNS). Interactions between inward-migrating sensory neuroblasts and emigrant cranial neural crest cells (NCCs) play a role in coordinating this process, but how the relationship between these ... More
Receptor tyrosine phosphatases guide vertebrate motor axons during development.
AuthorsStepanek L, Stoker AW, Stoeckli E, Bixby JL,
JournalJ Neurosci
PubMed ID15829633
Receptor-type protein tyrosine phosphatases (RPTPs) are required for appropriate growth of axons during nervous system development in Drosophila. In the vertebrate, type IIa RPTPs [protein tyrosine phosphatase (PTP)-delta, PTP-sigma, and LAR (leukocyte common-antigen-related)] and the type III RPTP, PTP receptor type O (PTPRO), have been implicated in the regulation of ... More
Neurofilament-M interacts with the D1 dopamine receptor to regulate cell surface expression and desensitization.
We used the yeast two-hybrid assay to identify novel proteins that interact with the D(1) dopamine receptor. The third cytoplasmic loop (residues 217-273) of the rat D(1) receptor was used as bait to identify clones encoding interacting proteins from a rat brain cDNA library. This identified two clones encoding the ... More
Boundary formation and compartition in the avian diencephalon.
AuthorsLarsen CW, Zeltser LM, Lumsden A,
JournalJ Neurosci
PubMed ID11425897
The diencephalon comprises three functionally distinct regions: synencephalon, dorsal thalamus, and ventral thalamus. Patterning of the diencephalon has been proposed to involve subdivision of its anteroposterior axis into segments, neuromeres or prosomeres (Bergquist and Kallen, 1954; Vaage, 1969; Figdor and Stern, 1993; Rubenstein et al., 1994; Redies et al., 2000; ... More
Exogenous growth factors induce the production of ganglion cells at the retinal margin.
AuthorsFischer AJ, Dierks BD, Reh TA,
JournalDevelopment
PubMed ID11959835
Neural progenitors at the retinal margin of the post-hatch chicken normally produce amacrine and bipolar cells, but not photoreceptor or ganglion cells. The purpose of this study was to test whether exogenous growth factors influence the types of cells produced by progenitors at the retinal margin. We injected insulin, FGF2 ... More
Cues from neuroepithelium and surface ectoderm maintain neural crest-free regions within cranial mesenchyme of the developing chick.
AuthorsGolding JP, Dixon M, Gassmann M,
JournalDevelopment
PubMed ID11874906
Within the developing vertebrate head, neural crest cells (NCCs) migrate from the dorsal surface of the hindbrain into the mesenchyme adjacent to rhombomeres (r)1 plus r2, r4 and r6 in three segregated streams. NCCs do not enter the intervening mesenchyme adjacent to r3 or r5, suggesting that these regions contain ... More
Distinct regulatory cascades for head and trunk myogenesis.
AuthorsMootoosamy RC, Dietrich S,
JournalDevelopment
PubMed ID11830559
Most head muscles arise from the pre-otic axial and paraxial head mesoderm. This tissue does not form somites, yet expresses the somitic markers Lbx1, Pax7 and Paraxis in a regionalised fashion. The domain set aside by these markers provides the lateral rectus muscle, the most caudal of the extrinsic eye ... More
Wnt2b controls retinal cell differentiation at the ciliary marginal zone.
AuthorsKubo F, Takeichi M, Nakagawa S
JournalDevelopment
PubMed ID12490564
The ciliary marginal zone of the vertebrate retina contains undifferentiated progenitor cells that continue to proliferate and add new neurons and glia peripherally during the embryonic stages - even after the formation of a functional retina. To understand the molecular mechanism that controls the prolonged progenitor cell proliferation in the ... More