Synapse-associated protein-97 isoform-specific regulation of surface AMPA receptors and synaptic function in cultured neurons.
AuthorsRumbaugh G, Sia GM, Garner CC, Huganir RL,
JournalJ Neurosci
PubMed ID12805297
'Members of the synapse-associated protein-97 (SAP97) family of scaffold proteins have been implicated as central organizers of synaptic junctions to build macromolecular signaling complexes around specific postsynaptic neurotransmitter receptors. In this regard, SAP97 has been suggested to regulate the synaptic localization of glutamate receptor type 1 subunits of the AMPA-type ... More
Traumatically induced axotomy adjacent to the soma does not result in acute neuronal death.
AuthorsSingleton RH, Zhu J, Stone JR, Povlishock JT,
JournalJ Neurosci
PubMed ID11826109
Traumatic axonal injury (TAI), a consequence of traumatic brain injury (TBI), results from progressive pathologic processes initiated at the time of injury. Studies attempting to characterize the pathology associated with TAI have not succeeded in following damaged and/or disconnected axonal segments back to their individual neuronal somata to determine their ... More