Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses.
AuthorsTinkle CL, Lechler T, Pasolli HA, Fuchs E,
JournalProc Natl Acad Sci U S A
PubMed ID14704278
'Loss of E-cadherin has been associated with human cancers, and yet in the early mouse embryo and the lactating mammary gland, the E-cadherin null state results in tissue dysfunction and cell death. Here we targeted loss of E-cadherin in skin epithelium. The epidermal basal layer responded by elevating P-cadherin, enabling ... More
Connexin expression and gap junctional coupling in human cumulus cells: contribution to embryo quality.
Gap junctional coupling among cumulus cells is important for oogenesis since its deficiency in mice leads to impaired folliculogenesis. Multiple connexins (Cx), the subunits of gap junction channels, have been found within ovarian follicles in several species but little is known about the connexins in human follicles. The aim of ... More