Tissue spreading on implantable substrates is a competitive outcome of cell-cell vs. cell-substratum adhesivity.
AuthorsRyan PL, Foty RA, Kohn J, Steinberg MS,
JournalProc Natl Acad Sci U S A
PubMed ID11274361
While the interactions of cells with polymeric substrata are widely studied, the influence of cell-cell cohesiveness on tissue spreading has not been rigorously investigated. Here we demonstrate that the rate of tissue spreading over a two-dimensional substratum reflects a competition or ... More
p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus.
AuthorsCiesiolka M, Delvaeye M, Van Imschoot G, Verschuere V, McCrea P, van Roy F, Vleminckx K,
JournalJ Cell Sci
PubMed ID15292404
During Xenopus development, p120 transcripts are enriched in highly morphogenetic tissues. We addressed the developmental function of p120 by knockdown experiments and by expressing E-cadherin mutants unable to bind p120. This resulted in defective eye formation and provoked malformations in the craniofacial cartilage structures, derivatives of the cranial neural crest ... More
The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm.
AuthorsMahlapuu M, Ormestad M, Enerbäck S, Carlsson P,
JournalDevelopment
PubMed ID11124112
The murine Foxf1 gene encodes a forkhead transcription factor expressed in extra-embryonic and lateral plate mesoderm and later in splanchnic mesenchyme surrounding the gut and its derivatives. We have disrupted Foxf1 and show that mutant embryos die at midgestation due to defects in mesodermal differentiation and cell adhesion. The embryos ... More