Targeting of Arf-1 to the early Golgi by membrin, an ER-Golgi SNARE.
AuthorsHonda A, Al-Awar OS, Hay JC, Donaldson JG,
JournalJ Cell Biol
PubMed ID15781476
'Arf and Rab family GTPases regulate membrane traffic in cells, yet little is known about how they are targeted to distinct organelles. To identify sequences in Arf-1 necessary for Golgi targeting, we examined the localization of chimeras between Arf-1 and Arf-6. Here, we identify a 16-amino acid sequence in Arf-1 ... More
WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function.
AuthorsAqeilan RI, Donati V, Palamarchuk A, Trapasso F, Kaou M, Pekarsky Y, Sudol M, Croce CM,
JournalCancer Res
PubMed ID16061658
The WW domain-containing oxidoreductase, WWOX, is a tumor suppressor that is deleted or altered in several cancer types. We recently showed that WWOX interacts with p73 and AP-2gamma and suppresses their transcriptional activity. Yes-associated protein (YAP), also containing WW domains, was shown to associate with p73 and enhance its transcriptional ... More
Akt phosphorylates Tal1 oncoprotein and inhibits its repressor activity.
AuthorsPalamarchuk A, Efanov A, Maximov V, Aqeilan RI, Croce CM, Pekarsky Y,
JournalCancer Res
PubMed ID15930267
The helix-loop-helix transcription factor Tal1 is required for blood cell development and its activation is a frequent event in T-cell acute lymphoblastic leukemia. The Akt (protein kinase B) kinase is a key player in transduction of antiapoptotic and proliferative signals in T cells. Because Tal1 has a putative Akt phosphorylation ... More
Isoforms of the polarity protein par6 have distinct functions.
AuthorsGao L, Macara IG,
JournalJ Biol Chem
PubMed ID15292221
PAR-6 is essential for asymmetric division of the Caenorhabditis elegans zygote. It is also critical for cell polarization in many other contexts throughout the Metazoa. The Par6 protein contains a PDZ domain and a partial CRIB (Cdc42/Rac interactive binding) domain, which mediate interactions with other polarity proteins such as Par3, ... More
Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress.
AuthorsChallagundla KB, Sun XX, Zhang X, DeVine T, Zhang Q, Sears RC, Dai MS
JournalMol Cell Biol
PubMed ID21807902
c-Myc promotes cell growth by enhancing ribosomal biogenesis and translation. Deregulated expression of c-Myc and aberrant ribosomal biogenesis and translation contribute to tumorigenesis. Thus, a fine coordination between c-Myc and ribosomal biogenesis is vital for normal cell homeostasis. Here, we show that ribosomal protein L11 regulates c-myc mRNA turnover. L11 ... More