Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia.
Authors Shin Jieun; Cho Hawon; Hwang Sun Wook; Jung Jooyoung; Shin Chan Young; Lee Soon-Youl; Kim So Hee; Lee Myung Gull; Choi Young Hae; Kim Jinwoong; Haber Nicole Alessandri; Reichling David B; Khasar Sachia; Levine Jon D; Oh Uhtaek;
JournalProc Natl Acad Sci U S A
PubMed ID12097645
The capsaicin-sensitive vanilloid receptor (VR1) was recently shown to play an important role in inflammatory pain (hyperalgesia), but the underlying mechanism is unknown. We hypothesized that pain-producing inflammatory mediators activate capsaicin receptors by inducing the production of fatty acid agonists of VR1. This study demonstrates that bradykinin, acting at B2 ... More