Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer.
AuthorsDumon KR, Ishii H, Vecchione A, Trapasso F, Baldassarre G, Chakrani F, Druck T, Rosato EF, Williams NN, Baffa R, During MJ, Huebner K, Croce CM,
JournalCancer Res
PubMed ID11406559
The fragile histidine triad (FHIT) gene is a tumor suppressor gene that is altered by deletion in a large fraction of human tumors, including pancreatic cancer. To evaluate the potential of FHIT gene therapy, we developed recombinant adenoviral and adenoassociated viral (AAV) FHIT vectors and tested these vectors in vitro ... More
Fibroblast growth factor and epidermal growth factor receptors in ligament healing.
AuthorsPanossian V, Liu SH, Lane JM, Finerman GA,
JournalClin Orthop Relat Res
PubMed ID9308540
Although recent in vivo studies indicate that basic fibroblast growth factor hastens the healing and strength of the medical collateral ligament after injury, in vitro studies with epidermal growth factor and basic fibroblast growth factor have shown increased fibroblast proliferation with the exogenous administration of these growth factors. Using an ... More