Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells.
AuthorsMüller N, Reinacher-Schick A, Baldus S, van Hengel J, Berx G, Baar A, van Roy F, Schmiegel W, Schwarte-Waldhoff I,
JournalOncogene
PubMed ID12203117
Smad4 is an intracellular transmitter of TGF-beta signals and its tumor suppressor function is presumed to reside in its capacity to mediate TGF-beta-induced growth inhibition. However, there is accumulating evidence that this hypothesis may be too simple. The roles of TGF-beta in carcinogenesis are complex and also comprise tumor promoting ... More
The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts.
AuthorsBraga VM, Machesky LM, Hall A, Hotchin NA
JournalJ Cell Biol
PubMed ID9182672
Cadherins are calcium-dependent cell-cell adhesion molecules that require the interaction of the cytoplasmic tail with the actin cytoskeleton for adhesive activity. Because of the functional relationship between cadherin receptors and actin filament organization, we investigated whether members of the Rho family of small GTPases are necessary for cadherin adhesion. In ... More