Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses.
AuthorsHoey T, Zhang S, Schmidt N, Yu Q, Ramchandani S, Xu X, Naeger LK, Sun YL, Kaplan MH,
JournalEMBO J
PubMed ID12912921
Signal transducer and activator of transcription (Stat)4 is a signaling molecule required for normal responses to interleukin-12 (IL-12) and is critically involved in inflammatory responses. We have isolated an alternatively spliced isoform of Stat4, termed Stat4beta, which lacks 44 amino acids at the C-terminus, encompassing the putative transcriptional activation domain. ... More
v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation.
AuthorsAkagi T, Shishido T, Murata K, Hanafusa H,
JournalProc Natl Acad Sci U S A
PubMed ID10852971
v-Crk induces cellular tyrosine phosphorylation and transformation of chicken embryo fibroblasts (CEF). We studied the molecular mechanism of the v-Crk-induced transformation. Experiments with Src homology (SH)2 and SH3 domain mutants revealed that the induction of tyrosine phosphorylation of cellular proteins requires only the SH2 domain, but both the SH2 and ... More