c-mip impairs podocyte proximal signaling and induces heavy proteinuria.
AuthorsZhang SY, Kamal M, Dahan K, Pawlak A, Ory V, Desvaux D, Audard V, Candelier M, BenMohamed F, Mohamed FB, Matignon M, Christov C, Decrouy X, Bernard V, Mangiapan G, Lang P, Guellaën G, Ronco P, Sahali D,
JournalSci Signal
PubMed ID20484117
Idiopathic nephrotic syndrome comprises several podocyte diseases of unknown origin that affect the glomerular podocyte, which controls the permeability of the filtration barrier in the kidney to proteins. It is characterized by the daily loss of more than 3 g of protein in urine and the lack of inflammatory lesions ... More
IL-10 administration reduces PGE-2 levels and promotes CR3-mediated clearance of Escherichia coli K1 by phagocytes in meningitis.
AuthorsMittal R, Gonzalez-Gomez I, Panigrahy A, Goth K, Bonnet R, Prasadarao NV,
JournalJ Exp Med
PubMed ID20498022
Ineffectiveness of antibiotics in treating neonatal Escherichia coli K1 meningitis and the emergence of antibiotic-resistant strains evidently warrants new prevention strategies. We observed that administration of interleukin (IL)-10 during high-grade bacteremia clears antibiotic-sensitive and -resistant E. coli from blood of infected mice. Micro-CT studies of brains from infected animals displayed ... More
Identification of a novel 12p13.3 amplicon in nasopharyngeal carcinoma.
AuthorsOr YY, Chung GT, To KF, Chow C, Choy KW, Tong CY, Leung AW, Hui AB, Tsao SW, Ng HK, Yip TT, Busson P, Lo KW,
JournalJ Pathol
PubMed ID19718711
Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer commonly occurring in southern China. To decipher the molecular basis of this cancer, we performed high-resolution array CGH analysis on eight tumour lines and 10 primary tumours to identify the genes involved in NPC tumorigenesis. In this study, ... More
Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system.
AuthorsWang Q, Peng Y, Chen S, Gou X, Hu B, Du J, Lu Y, Xiong L,
JournalStroke
PubMed ID19372445
Our previous study demonstrated that pretreatment with electroacupuncture (EA) induces rapid tolerance to focal cerebral ischemia. The present study was aimed to investigate the involvement of the endocannabinoid system in the early neuroprotection conferred by EA pretreatment in the animal model of focal cerebral ischemia. Two hours after the end ... More
Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress.
AuthorsTront JS, Huang Y, Fornace AJ, Fornace AA, Hoffman B, Liebermann DA,
JournalCancer Res
PubMed ID21098706
Gadd45a plays a pivotal role as a stress sensor that modulates cellular responses to various stress stimuli including oncogenic stress. We reported that the stress sensor Gadd45a gene functions as a tumor suppressor in Ras-driven breast tumorigenesis via increasing JNK-mediated apoptosis and p38-mediated senescence. In contrast, here, we show that ... More
Escherichia coli K1 promotes the ligation of CD47 with thrombospondin-1 to prevent the maturation of dendritic cells in the pathogenesis of neonatal meningitis.
AuthorsMittal R, Gonzalez-Gomez I, Prasadarao NV,
JournalJ Immunol
PubMed ID20675593
Dendritic cells (DCs) are professional APCs providing a critical link between adaptive and innate immune responses. Our previous studies have shown that Escherichia coli K1 internalization of myeloid DCs suppressed the maturation of the cells for which outer membrane protein A (OmpA) expression is essential. In this study, we demonstrate ... More
Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice.
AuthorsKim SS, Wang H, Li XY, Chen T, Mercaldo V, Descalzi G, Wu LJ, Zhuo M,
JournalMol Brain
PubMed ID21247477
ABSTRACT: Affective disorders, which include anxiety and depression, are highly prevalent and have overwhelming emotional and physical symptoms. Despite human brain imaging studies, which have implicated the prefrontal cortex including the anterior cingulate cortex (ACC), little is known about the ACC in anxiety disorders. Here we show that the ACC ... More
Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration.
AuthorsSudo H, Minami A,
JournalArthritis Rheum
PubMed ID21305515
OBJECTIVE.: Although the etiology of intervertebral disc degeneration is poorly understood, one possible approach for its regulation includes apoptosis inhibition. We investigated the anti-apoptotic effects of caspase 3 in intervertebral disc degeneration. METHODS.: We investigated the effects of caspase 3 short interfering RNA (siRNA) on rabbit nucleus pulposus (NP) cells ... More
Growth hormone promotes the survival of retinal cells in vivo.
AuthorsSanders EJ, Lin WY, Parker E, Harvey S,
JournalGen Comp Endocrinol
PubMed ID21185293
Growth hormone (GH) is synthesized and present in the developing chick retina, where it may have local actions in retinal cell differentiation similar to those of conventional growth factors. We have previously shown that retinal GH has neuroprotective effects in retinal ganglion cells. In this paper, we extend our earlier ... More