Gap junction adhesion is necessary for radial migration in the neocortex.
AuthorsElias LA, Wang DD, Kriegstein AR,
JournalNature
PubMed ID17713529
'Radial glia, the neuronal stem cells of the embryonic cerebral cortex, reside deep within the developing brain and extend radial fibres to the pial surface, along which embryonic neurons migrate to reach the cortical plate. Here we show that the gap junction subunits connexin 26 (Cx26) and connexin 43 (Cx43) ... More
Functional heterotypic interactions between astrocyte and oligodendrocyte connexins.
AuthorsMagnotti LM, Goodenough DA, Paul DL
JournalGlia
PubMed ID21046554
'Human genetic diseases and mouse knockouts illustrate that the maintenance of central nervous system myelin requires connexin expression by both astrocytes and oligodendrocytes. Because these cell types express nonoverlapping sets of connexins, the intercellular channels formed between them must be asymmetric with regard to connexin content, defined as heterotypic. Here, ... More
Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1.
AuthorsLi X, Olson C, Lu S, Kamasawa N, Yasumura T, Rash JE, Nagy JI,
JournalEur J Neurosci
PubMed ID15090040
'Among the 20 members in the connexin family of gap junction proteins, only connexin36 (Cx36) is firmly established to be expressed in neurons and to form electrical synapses at widely distributed interneuronal gap junctions in mammalian brain. Several connexins have recently been reported to interact with the PDZ domain-containing protein ... More
Loss of Cadherin-Binding Proteins ß-Catenin and Plakoglobin in the Heart Leads to Gap Junction Remodeling and Arrhythmogenesis.
AuthorsSwope D, Cheng L, Gao E, Li J, Radice GL,
JournalMol Cell Biol
PubMed ID22252313
Arrhythmic right ventricular cardiomyopathy (ARVC) is a hereditary heart muscle disease that causes sudden cardiac death (SCD) in young people. Almost half of ARVC patients have a mutation in genes encoding cell adhesion proteins of the desmosome, including plakoglobin (JUP). We previously reported that cardiac tissue-specific plakoglobin (PG) knockout (PG ... More
Neuronal connexin expression in the cochlear nucleus of big brown bats.
AuthorsHorowitz SS, Stamper SA, Simmons JA,
JournalBrain Res
PubMed ID18241843
We present immunohistochemical data describing the presence and distribution of connexins, structural component of gap junctions, in the cochlear nuclei of adult big brown bats (Eptesicus fuscus). Echolocating big brown bats show microsecond scale echo-delay sensitivity that requires accurate synchronization of neuronal responses to the timing of echoes. Midbrain and ... More
Connexin30 in rodent, cat and human brain: selective expression in gray matter astrocytes, co-localization with connexin43 at gap junctions and late developmental appearance.
AuthorsNagy JI, Patel D, Ochalski PA, Stelmack GL
JournalNeuroscience
PubMed ID10197766
We previously presented evidence [Nagy et al. (1997) Neuroscience 78, 533-548] that, in addition to their ubiquitous expression of connexin43, astrocytes produce a second connexin suggested to be connexin30, a recently discovered member of the family of gap junction proteins. A connexin30 specific antibody was subsequently developed and utilized here ... More