Axon behavior in the olfactory nerve reflects the involvement of catenin-cadherin mediated adhesion.
AuthorsAkins MR, Greer CA
JournalJ Comp Neurol
PubMed ID17072833
'The projection of olfactory sensory neuron (OSN) axons to the olfactory bulb (OB) is a complex but well-regulated process. Although odorant receptor proteins, and other molecules, are implicated in this process, our understanding remains incomplete. We demonstrate that axons remain restricted to the outer olfactory nerve layer (ONLo) until they ... More
Monocytes induce reversible focal changes in vascular endothelial cadherin complex during transendothelial migration under flow.
AuthorsAllport JR, Muller WA, Luscinskas FW,
JournalJ Cell Biol
PubMed ID10629229
'The vascular endothelial cell cadherin complex (VE-cadherin, alpha-, beta-, and gamma-catenin, and p120/p100) localizes to adherens junctions surrounding vascular endothelial cells and may play a critical role in the transendothelial migration of circulating blood leukocytes. Previously, we have reported that neutrophil adhesion to human umbilical vein endothelial cell (HUVEC) monolayers, ... More
Distinct subcellular expression of endogenous polycystin-2 in the plasma membrane and Golgi apparatus of MDCK cells.
AuthorsScheffers MS, Le H, van der Bent P, Leonhard W, Prins F, Spruit L, Breuning MH, de Heer E, Peters DJ,
JournalHum Mol Genet
PubMed ID11772999
'Polycystin-2 is a predicted integral membrane protein with non-selective cation channel activity. The protein is encoded by the PKD2 gene, which is mutated in approximately 15% of patients with autosomal dominant polycystic kidney disease (ADPKD). Polycystin-2 can interact with the transmembrane protein polycystin-1, the product of the PKD1 gene. However, ... More
Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice.
AuthorsCarothers AM, Melstrom KA, Mueller JD, Weyant MJ, Bertagnolli MM,
JournalJ Biol Chem
PubMed ID11483600
The C57BL/6J-Min/+ (Min/+) mouse bears a mutant Apc gene and therefore is an important in vivo model of intestinal tumorigenesis. Min/+ mice develop adenomas that exhibit loss of the wild-type Apc allele (Apc(Min/-)). Previously, we found that histologically normal enterocytes bearing a truncated Apc protein (Apc(Min/+)) migrated more slowly in ... More
Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption of the vascular endothelial-cadherin complex at endothelial cell-to-cell junctions.
Although several adhesion molecules expressed on leukocytes (beta1 and beta2 integrins, platelet endothelial cell adhesion molecule 1 [PECAM-1], and CD47) and on endothelium (intercellular adhesion molecule 1, PECAM-1) have been implicated in leukocyte transendothelial migration, less is known about the role of endothelial lateral junctions during this process. We have ... More
Melanoma prognostic model using tissue microarrays and genetic algorithms.
As a result of the questionable risk-to-benefit ratio of adjuvant therapies, stage II melanoma is currently managed by observation because available clinicopathologic parameters cannot identify the 20% to 60% of such patients likely to develop metastatic disease. Here, we propose a multimarker molecular prognostic assay that can help triage patients ... More
a-Catenin contributes to the strength of E-cadherin-p120 interactions.
AuthorsTroyanovsky RB, Klingelhöfer J, Troyanovsky SM
JournalMol Biol Cell
PubMed ID21937720
Cadherin-catenin interactions play an important role in cadherin-mediated adhesion. Here we present strong evidence that in the cadherin-catenin complex a-catenin contributes to the binding strength of another catenin, p120, to the same complex. Specifically, we found that a ß-catenin-uncoupled cadherin mutant interacts much more weakly with p120 than its full-size ... More