HIV-1 Vpr Induces Apoptosis through Caspase 9 in T Cells and Peripheral Blood Mononuclear Cells.
Authors Muthumani Karuppiah; Hwang Daniel S; Desai Brijal M; Zhang Donghui; Dayes Nathanael; Green Douglas R; Weiner David B;
JournalJ Biol Chem
PubMed ID12095993
Human immunodeficiency virus, type 1 (HIV-1), vpr gene encodes a 14-kDa virion-associated protein, which exhibits significant effects on human cells. One important property of Vpr is its ability to induce apoptosis during infection. Apoptotic induction is likely to play a role in the pathogenesis of AIDS. However, the pathway of ... More