View additional product information for EcoRI - Citations (15202013)
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Abstract
TAT protein transduction into isolated perfused hearts: TAT-apoptosis repressor with caspase recruitment domain is cardioprotective.
Authors Gustafsson Asa B; Sayen M Richard; Williams Scott D; Crow Michael T; Gottlieb Roberta A;
JournalCirculation
PubMed ID12163436
'BACKGROUND: Linkage of the 11-amino-acid transduction domain of HIV TAT to a heterologous protein allows the protein to be transduced readily into cells. METHODS AND RESULTS: In this study, we inserted the apoptosis repressor with caspase recruitment domain (ARC) or beta-galactosidase (beta-gal) cDNA into the pTAT-hemagglutinin bacterial expression vector to ... More
Principles of 3' splice site selection and alternative splicing for an unusual group II intron from Bacillus anthracis.
AuthorsRobart AR, Montgomery NK, Smith KL, Zimmerly S,
JournalRNA
PubMed ID15100440
We investigated the self-splicing properties of two introns from the bacterium Bacillus anthracis. One intron (B.a.I1) splices poorly in vitro despite having typical structural motifs, while the second (B.a.I2) splices well while having apparently degenerated features. The spliced exons of B.a.I2 were sequenced, and splicing was found to occur at ... More
Identification of amino acid residues critical for biological activity in human interleukin-18.
Authors Kim Soo-Hyun; Azam Tania; Novick Daniela; Yoon Do-Young; Reznikov Leonid L; Bufler Philip; Rubinstein Menachem; Dinarello Charles A;
JournalJ Biol Chem
PubMed ID11790772
Interleukin-18 (IL-18) is a pro-inflammatory cytokine, and IL-18-binding protein (IL-18BP) is a naturally occurring protein that binds IL-18 and neutralizes its biological activities. Computer modeling of human IL-18 identified two charged residues, Glu-42 and Lys-89, which interact with oppositely charged amino acid residues buried in a large hydrophobic pocket of ... More