Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.
AuthorsDiskin SJ, Capasso M, Schnepp RW, Cole KA, Attiyeh EF, Hou C, Diamond M, Carpenter EL, Winter C, Lee H, Jagannathan J, Latorre V, Iolascon A, Hakonarson H, Devoto M, Maris JM,
JournalNat Genet
PubMed ID22941191
Neuroblastoma is a cancer of the sympathetic nervous system that accounts for approximately 10% of all pediatric oncology deaths. Here, we report a genome-wide association study of 2,817 neuroblastoma cases and 7,473 controls. We identified two new associations at 6q16, the first within HACE1 (rs4336470; combined P=2.7×10(-11); odds ratio 1.26, ... More
Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease.
AuthorsCisternas P, Zolezzi JM, Martinez M, Torres VI, Wong GW, Inestrosa NC
JournalJ Neurochem
PubMed ID30300917
'Dysregulated Wnt signaling is linked to major neurodegenerative diseases, including Alzheimer disease (AD). In mouse models of AD, activation of the canonical Wnt signaling pathway improves learning/memory, but the mechanism for this remains unclear. The decline in brain function in AD patients correlates with reduced glucose utilization by neurons. Here, ... More
Human antigen R protein modulates vascular endothelial growth factor expression in human corneal epithelial cells under hypoxia.
AuthorsHung KF, Sun YC, Liou HM, Hu FR
JournalJ Formos Med Assoc
PubMed ID31262614
'Corneal avascularity is critical for corneal transparency; therefore, a tailored process has been presumed to minimize corneal neovascularization (NV). In most cell types, the transcription of vascular endothelial growth factor (VEGF) is up-regulated, and the stability of VEGF mRNA is sustained by human antigen R (HuR) during hypoxia; however, whether ... More
Increased O-GlcNAcylation of c-Myc Promotes Pre-B Cell Proliferation.
AuthorsLee DH, Kwon NE, Lee WJ, Lee MS, Kim DJ, Kim JH, Park SK
JournalCells
PubMed ID31936366
O-linked ß-N-acetylglucosamine (O-GlcNAc) modification regulates the activity of hundreds of nucleocytoplasmic proteins involved in a wide variety of cellular processes, such as gene expression, signaling, and cell growth; however, the mechanism underlying the regulation of B cell development and function by O-GlcNAcylation remains largely unknown. Here, we demonstrate that changes ... More