Folding of Dimeric Methionine Adenosyltransferase III. IDENTIFICATION OF TWO FOLDING INTERMEDIATES.
Authors Sanchez Del Pino Manuel M; Perez-Mato Isabel; Sanz Jesus M; Mato Jose M; Corrales Fernando J;
JournalJ Biol Chem
PubMed ID11815619
Methionine adenosyl transferase (MAT) is an essential enzyme that synthesizes AdoMet. The liver-specific MAT isoform, MAT III, is a homodimer of a 43.7-kDa subunit that organizes in three nonsequential alpha-beta domains. Although MAT III structure has been recently resolved, little is known about its folding mechanism. Equilibrium unfolding and refolding ... More