Repair of Sequence-specific 125I-induced Double-strand Breaks by Nonhomologous DNA End Joining in Mammalian Cell-free Extracts.
Authors Odersky Andrea; Panyutin Irina V; Panyutin Igor G; Schunck Christian; Feldmann Elke; Goedecke Wolfgang; Neumann Ronald D; Obe Gunter; Pfeiffer Petra;
JournalJ Biol Chem
PubMed ID11821407
In mammalian cells, nonhomologous DNA end joining (NHEJ) is considered the major pathway of double-strand break (DSB) repair. Rejoining of DSB produced by decay of (125)I positioned against a specific target site in plasmid DNA via a triplex-forming oligonucleotide (TFO) was investigated in cell-free extracts from Chinese hamster ovary cells. ... More