Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy.
Authors Pai Rama; Soreghan Brian; Szabo Imre L; Pavelka Meredith; Baatar Dolgor; Tarnawski Andrzej S;
JournalNat Med
PubMed ID11875501
'Prostaglandins (PGs), bioactive lipid molecules produced by cyclooxygenase enzymes (COX-1 and COX-2), have diverse biological activities, including growth-promoting actions on gastrointestinal mucosa. They are also implicated in the growth of colonic polyps and cancers. However, the precise mechanisms of these trophic actions of PGs remain unclear. As activation of the ... More