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Abstract
Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research.
AuthorsJan A, Hartley DM, Lashuel HA,
JournalNat Protoc
PubMed ID20539293
'The amyloid cascade hypothesis, supported by strong evidence from genetics, pathology and studies using animal models, implicates amyloid-beta (Abeta) oligomerization and fibrillogenesis as central causative events in the pathogenesis of Alzheimer''s disease (AD). Today, significant efforts in academia, biotechnology and the pharmaceutical industry are devoted to identifying the mechanisms by ... More
Investigating conversion of mechanical force into biochemical signaling in three-dimensional chondrocyte cultures.
AuthorsBougault C, Paumier A, Aubert-Foucher E, Mallein-Gerin F,
JournalNat Protoc
PubMed ID19478808
The culture of chondrocytes embedded within agarose hydrogels maintains chondrocytic phenotype over extended periods and allows analysis of the chondrocyte response to mechanical forces. The mechanisms involved in the transduction of a mechanical stimulus to a physiological process are not completely deciphered. We present protocols to prepare and characterize constructs ... More