Comparing Effects of Transforming Growth Factor ß1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels.
AuthorsLively S, Lam D, Wong R, Schlichter LC
JournalFront Cell Neurosci
PubMed ID29780305
'The cytokine, transforming growth factor ß1 (TGFß1), is up-regulated after central nervous system (CNS) injuries or diseases involving microglial activation, and it has been proposed as a therapeutic agent for treating neuroinflammation. Microglia can produce and respond to TGFß1. While rats and mice are commonly used for studying neuroinflammation, very ... More
Re-Defining Stem Cell-Cardiomyocyte Interactions: Focusing on the Paracrine Effector Approach.
AuthorsMahapatra S, Martin D, Gallicano GI
JournalJ Stem Cells Regen Med
PubMed ID30018469
'Stem cell research for treating or curing ischemic heart disease has, till date, culminated in three basic approaches: the use of induced pluripotent stem cell (iPSC) technology; reprogramming cardiac fibroblasts; and cardiovascular progenitor cell regeneration. As each approach has been shown to have its advantages and disadvantages, exploiting the advantages ... More
Microglia Responses to Pro-inflammatory Stimuli (LPS, IFN?+TNFa) and Reprogramming by Resolving Cytokines (IL-4, IL-10).
AuthorsLively S, Schlichter LC
JournalFront Cell Neurosci
PubMed ID30087595
Microglia respond to CNS injuries and diseases with complex reactions, often called "activation." A pro-inflammatory phenotype (also called classical or M1 activation) lies at one extreme of the reactivity spectrum. There were several motivations for this study. First, bacterial endotoxin (lipopolysaccharide, LPS) is the most commonly used pro-inflammatory stimulus for ... More
Polarized Human Retinal Pigment Epithelium Exhibits Distinct Surface Proteome on Apical and Basal Plasma Membranes.
AuthorsKhristov V, Wan Q, Sharma R, Lotfi M, Maminishkis A, Bharti K
JournalMethods Mol Biol
PubMed ID29264809
Surface proteins localized on the apical and basal plasma membranes are required for a cell to sense its environment and relay changes in ionic, cytokine, chemokine, and hormone levels to the inside of the cell. In a polarized cell, surface proteins are differentially localized on the apical or the basolateral ... More