Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos.
AuthorsBendahmane M, Morales A, Kreutzberger AJB, Schenk NA, Mohan R, Bakshi S, Philippe JM, Zhang S, Kiessling V, Tamm LK, Giovannucci DR, Jenkins PM, Anantharam A
JournalJ Neurochem
PubMed ID32058590
Synaptotagmin-7 (Syt-7) is one of two major calcium sensors for exocytosis in adrenal chromaffin cells, the other being synaptotagmin-1 (Syt-1). Despite a broad appreciation for the importance of Syt-7, questions remain as to its localization, function in mediating discharge of dense core granule cargos, and role in triggering release in ... More