Identification of early-stage colorectal cancer patients at risk of relapse post-resection by immunobead reverse transcription-PCR analysis of peritoneal lavage fluid for malignant cells.
AuthorsLloyd JM, McIver CM, Stephenson SA, Hewett PJ, Rieger N, Hardingham JE,
JournalClin Cancer Res
PubMed ID16428481
PURPOSE: Colorectal cancer patients diagnosed with stage I or II disease are not routinely offered adjuvant chemotherapy following resection of the primary tumor. However, up to 10% of stage I and 30% of stage II patients relapse within 5 years of surgery from recurrent or metastatic disease. The aim of ... More
Evaluation of a panel of tumor markers for molecular detection of circulating cancer cells in women with suspected breast cancer.
AuthorsReinholz MM, Nibbe A, Jonart LM, Kitzmann K, Suman VJ, Ingle JN, Houghton R, Zehentner B, Roche PC, Lingle WL,
JournalClin Cancer Res
PubMed ID15897569
PURPOSE: We examined the feasibility of using molecular characterization of circulating tumor cells as a method for early detection of breast cancer. RESEARCH DESIGN: Women without a prior history of cancer who had a breast abnormality detected on imaging followed by a breast biopsy were enrolled in this study. Density ... More