c-Src-dependent transcriptional activation of TFII-I.
Authors Cheriyath Venugopalan; Desgranges Zana Patrick; Roy Ananda L;
JournalJ Biol Chem
PubMed ID11934902
'TFII-I is a multifunctional transcription factor that is also involved in signal transduction. Here we show that TFII-I undergoes a c-Src-dependent tyrosine phosphorylation on tyrosine residues 248 and 611 and translocates to the nucleus in response to growth factor signaling. Tyrosine-phosphorylated nuclear TFII-I activates a stably integrated c-fos reporter gene. ... More