'The purpose of this study was to investigate the neuroprotective effect of a water-soluble formulation of coenzyme Q10 (WS-CoQ10) in PC12 cells exposed to cisplatin, a chemotherapeutic agent with a dose-limiting factor due to neurotoxicity. In the cytokinesis-block micronucleus cytome assay (CBMN Cyt), WS-CoQ10 (at concentrations of 0.1, 0.5 and ... More
Spontaneous glycine-induced calcium transients in spinal cord progenitors promote neurogenesis.
AuthorsBrustein E, Côté S, Ghislain J, Drapeau P
JournalDev Neurobiol
PubMed ID22888055
Glycine and GABA are depolarizing during early development, but the purpose of this paradoxical chloride-mediated depolarization remains unclear, especially at early stages. It was previously reported that suppressing glycine signaling from the beginning of development in zebrafish embryos caused an abnormal maintenance of the progenitor population and a specific reduction ... More
Cytotoxicity and DNA fragmentation properties of butylated hydroxyanisole.
AuthorsVandghanooni S, Forouharmehr A, Eskandani M, Barzegari A, Kafil V, Kashanian S, Ezzati Nazhad Dolatabadi J
JournalDNA Cell Biol
PubMed ID23413972
Butylated hydroxyanisole (BHA) is a synthetic phenolic food additive that is used to prevent oils, fats, and shortenings from oxidative deterioration and rancidity. It was tested for potential cytotoxicity and genotoxicity upon A549 lung cancer cells. MTT assay and flow cytometry analysis were used for cytotoxicity assessment, whereas genotoxicity was ... More
A short cis-acting motif in the M112-113 promoter region is essential for IE3 to activate M112-113 gene expression and is important for murine cytomegalovirus replication.
Immediate-early 3 (IE3) gene products are required to activate early (E)-stage gene expression of murine cytomegaloviruses (MCMV). The first early gene activated by IE3 is the M112-113 gene (also called E1), although a complete understanding of the activation mechanism is still lacking. In this paper, we identify a 10-bp cis-regulating ... More
A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity.
AuthorsBiasini E, Unterberger U, Solomon IH, Massignan T, Senatore A, Bian H, Voigtlaender T, Bowman FP, Bonetto V, Chiesa R, Luebke J, Toselli P, Harris DA
JournalJ Neurosci
PubMed ID23392670
Growing evidence suggests that a physiological activity of the cellular prion protein (PrP(C)) plays a crucial role in several neurodegenerative disorders, including prion and Alzheimer's diseases. However, how the functional activity of PrP(C) is subverted to deliver neurotoxic signals remains uncertain. Transgenic (Tg) mice expressing PrP with a deletion of ... More
Investigation of biological activities of dichloromethane and ethyl acetate fractions of Platonia insignis Mart. seed.
AuthorsCosta Júnior JS, Ferraz AB, Sousa TO, Silva RA, De Lima SG, Feitosa CM, Citó AM, Melo Cavalcante AA, Freitas RM, Moura Sperotto AR, Péres VF, Moura DJ, Saffi J
JournalBasic Clin Pharmacol Toxicol
PubMed ID22788872
Platonia insignis Mart., a native species of the Brazilian Amazon more commonly known as bacuri, is a member of the Clusiaceae family. In this study, we evaluated the chemical composition and the antioxidant and toxicity activities of the dichloromethane and ethyl acetate fractions from P. insignis seed ethanolic extract using different ... More