Restoration of blood flow by using continuous perimuscular infiltration of plasmid DNA encoding subterranean mole rat Spalax ehrenbergi VEGF.
AuthorsRoguin A, Avivi A, Nitecki S, Rubinstein I, Levy NS, Abassi ZA, Resnick MB, Lache O, Melamed-Frank M, Joel A, Hoffman A, Nevo E, Levy AP,
JournalProc Natl Acad Sci U S A
PubMed ID12672967
'The optimal vector, regulatory sequences, and method of delivery of angiogenic gene therapy are of considerable interest. The Spalax ehrenbergi superspecies live in subterranean burrows at low oxygen tensions and its tissues are highly vascularized. We tested whether continuous perimuscular administration of Spalax vascular endothelial growth factor (VEGF) DNA could ... More