Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems.
AuthorsLiedtke W, Leman EE, Fyffe RE, Raine CS, Schubart UK,
JournalAm J Pathol
PubMed ID11839567
Stathmin is a cytosolic protein that binds tubulin and destabilizes cellular microtubules, an activity regulated by phosphorylation. Despite its abundant expression in the developing mammalian nervous system and despite its high degree of evolutionary conservation, stathmin-deficient mice do not exhibit a developmental phenotype.(1) Here we report that aging stathmin(-/-) mice ... More