'The photoreceptor is a highly polarized neuron and also has epithelial characteristics such as adherens junctions. To investigate the mechanisms of polarity formation of the photoreceptor cells, we conditionally knocked out atypical protein kinase Clambda (aPKClambda), which has been proposed to play a critical role in the establishment of epithelial ... More
Is mammary not otherwise specified-type sarcoma with CD10 expression a distinct entity? A rare case report with immunohistochemical and ultrastructural study.
AuthorsYang GZ, Li J, Jin H, Ding HY,
JournalDiagn Pathol
PubMed ID23356903
'Mammary sarcoma is extremely rare and the diagnosis is established only after metaplastic carcinomas and malignant phyllodes tumours are excluded. A rare case of not otherwise specified-type sarcoma with CD10 expression in the left breast in a 45-year-old female was presented. It was a high-grade tumour composed of spindle cells ... More
Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology.
AuthorsRyeom SW, Paul D, Goodenough DA,
JournalMol Biol Cell
PubMed ID10793144
'The tight junction is the most apical intercellular junction of epithelial cells and regulates transepithelial permeability through the paracellular pathway. To examine possible functions for the tight junction-associated protein ZO-1, C-terminally truncated mutants and a deletion mutant of ZO-1 were epitope tagged and stably expressed in corneal epithelial cell lines. ... More
Matrigel improves functional properties of primary human salivary gland cells.
AuthorsMaria OM, Zeitouni A, Gologan O, Tran SD
JournalTissue Eng Part A
PubMed ID21189069
'Currently, there is no effective treatment available to patients with irreversible loss of functional salivary acini caused by Sjogren''s syndrome or after radiotherapy for head and neck cancer. A tissue-engineered artificial salivary gland would help these patients. The graft cells for this device must establish tight junctions in addition to ... More
Mesenchymal stem cells in infantile hemangioma reside in the perivascular region.
'Infantile hemangioma grows quickly in the first year of life and regresses slowly to fibrofatty tissue during childhood; mesenchymal stem cells (MSCs) have been reported to contribute to this adipogenesis. Recent studies have shown the perivascular origin of MSCs in multiple organs. We hypothesized that MSCs in hemangioma might also ... More
Inhibition of matrix metalloproteinases prevents the synthesis of insulin-like growth factor binding protein-1 during decidualization in the baboon.
AuthorsStrakova Z, Szmidt M, Srisuparp S, Fazleabas AT,
JournalEndocrinology
PubMed ID12960035
'During pregnancy in the primate, uterine stromal fibroblasts are transformed into decidual cells. Decidualization is associated with extensive remodeling of the extracellular matrix (ECM). Matrix metalloproteinases (MMPs) play a pivotal role in ECM degradation. We hypothesized that MMPs also contribute to regulation of IGF binding protein-1 (IGFBP-1), a biochemical marker ... More
Inhibition of IDO1 suppresses cyclooxygenase-2 and matrix metalloproteinase-9 expression and decreases proliferation, adhesion and invasion of endometrial stromal cells.
AuthorsMei J, Jin LP, Ding D, Li MQ, Li DJ, Zhu XY,
JournalMol Hum Reprod
PubMed ID22638210
'Indoleamine 2,3-dioxygenase-1 (IDO1) is an intracellular enzyme that catalyses essential amino acid tryptophan along the kynurenine pathway. The aim of this study was to determine the impact of IDO1 expression on the biological characteristic of the endometrial stromal cells (ESCs). IDO1, cyclooxygenase-2 (COX-2) and matrix metalloproteinases (MMPs) in endometriotic ectopic ... More
Clinical significance of E-cadherin, ß-catenin, vimentin and S100A4 expression in completely resected squamous cell lung carcinoma.
AuthorsZhang H, Liu J, Yue D, Gao L, Wang D, Zhang H, Wang C,
Journal
PubMed ID23853314
'The aim of this study was to evaluate the prognostic value of E-cadherin, ß-catenin, vimentin and S100A4 expression in a cohort of squamous cell lung carcinoma (SqCC) patients. Tumours from 204 patients with surgically resected SqCC were used for the immunohistochemical analyses of E-cadherin, ß-catenin, vimentin and S100A4 expression. Correlations ... More
Juxtaglomerular cell tumor of kidney with CD34 and CD117 immunoreactivity: report of 5 cases.
AuthorsKim HJ, Kim CH, Choi YJ, Ayala AG, Amirikachi M, Ro JY
JournalArch Pathol Lab Med
PubMed ID16683889
Juxtaglomerular cell tumor is a rare renal neoplasm. Renin immunohistochemistry and electron microscopic documentation of rhomboid crystals are the primary methods of diagnosing this benign tumor. ... More
Neuroprotective Effects of Direct Intrathecal Administration of Granulocyte Colony-Stimulating Factor in Rats with Spinal Cord Injury.
AuthorsChen WF, Chen CH, Chen NF, Sung CS, Wen ZH
Journal
PubMed ID26190345
To date, no reliable methods have proven effective for treating spinal cord injury (SCI). Even systemic administration of methylprednisolone (MP) remains controversial. We previously reported that intrathecal (i.t.) administration of granulocyte colony-stimulating factor (G-CSF) improves outcome after experimental spinal cord ischemic insults in rats. The present study aimed to examine ... More
Bizarre leiomyoma of the scrotum.
AuthorsKim NR, Sung CO, Han J,
JournalJ Korean Med Sci
PubMed ID12808340
Scrotal leiomyomas with atypical bizarre nuclei are rare, which might be misdiagnosed as malignant tumor. We describe a case of scrotal bizarre leiomyoma in a 65-yr-old man. The tumor was a 1 cm-sized, well circumscribed, oval mass arising from the tunica dartos muscle. Histologically, it was formed by whorling bundles ... More
The unique simultaneous occurrence of granular cell tumor, gastrointestinal stromal tumor, and gastric adenocarcinoma.
AuthorsSailors JL, French SW
JournalArch Pathol Lab Med
PubMed ID15859656
Granular cell tumors are generally benign oncocytoid lesions of schwannian origin that are often incidental findings in many locations. Gastrointestinal stromal tumors occur in older adults and express the c-Kit protein (CD117). Both of these tumors have been described in association with many other entities; however, they have never been ... More
Renal cell carcinomas with t(6;11)(p21;q12) presenting with tubulocystic renal cell carcinoma-like features.
AuthorsRao Q, Zhang XM, Tu P, Xia QY, Shen Q, Zhou XJ, Shi QL,
Journal
PubMed ID23826432
In this study, we reported an additional genetically confirmed case of renal cell carcinomas (RCCs) with t(6;11)(p21;q12) showing an unusual histological pattern. Histologically, the tumor was entirely composed of small to intermediate sized tubules and cysts. The tubules and cysts were lined by a single layer of flat, hobnail, cuboidal ... More
The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition.
AuthorsSavagner P, Yamada KM, Thiery JP
JournalJ Cell Biol
PubMed ID9182671
Epithelial-mesenchymal transition (EMT) is an essential morphogenetic process during embryonic development. It can be induced in vitro by hepatocyte growth factor/scatter factor (HGF/SF), or by FGF-1 in our NBT-II cell model for EMT. We tested for a central role in EMT of a zinc-finger protein called Slug. Slug mRNA and ... More
Aspirin blocks growth of breast tumor cells and tumor-initiating cells and induces reprogramming factors of mesenchymal to epithelial transition.
AuthorsMaity G, De A, Das A, Banerjee S, Sarkar S, Banerjee SK
Journal
PubMed ID25867761
Acetylsalicylic acid (ASA), also known as aspirin, a classic, nonsteroidal, anti-inflammatory drug (NSAID), is widely used to relieve minor aches and pains and to reduce fever. Epidemiological studies and other experimental studies suggest that ASA use reduces the risk of different cancers including breast cancer (BC) and may be used ... More