'Adult hippocampal neurogenesis results in the continuous formation of new neurons and is a process of brain plasticity involved in learning and memory. The neurogenic niche regulates the stem cell proliferation and the differentiation and survival of new neurons and a major contributor to the neurogenic niche are astrocytes. Among ... More
Deficits of peripheral olfactory inputs reduce cell proliferation in the adult subventricular and subgranular zones.
AuthorsXu Z, Gao Y, Xu F,
JournalNeurosci Lett
PubMed ID23454284
'Constitutive adult neurogenesis mainly occurs in the subgranular zone (SGZ) and subventricular zone (SVZ) of the mammalian brain. Intrinsic and extrinsic factors regulate adult neurogenesis processes including cell proliferation, migration, integration and neural survival. The potential contribution of olfactory sensory input to the regulation of adult neurogenesis, especially neurogenesis in ... More
Cerebral cell renewal in adult mice controls the onset of obesity.
AuthorsGouazé A, Brenachot X, Rigault C, Krezymon A, Rauch C, Nédélec E, Lemoine A, Gascuel J, Bauer S, Pénicaud L, Benani A,
Journal
PubMed ID23967273
'The hypothalamus plays a crucial role in the control of the energy balance and also retains neurogenic potential into adulthood. Recent studies have reported the severe alteration of the cell turn-over in the hypothalamus of obese animals and it has been proposed that a neurogenic deficiency in the hypothalamus could ... More
X-ray fluorescence imaging: a new tool for studying manganese neurotoxicity.
AuthorsRobison G, Zakharova T, Fu S, Jiang W, Fulper R, Barrea R, Marcus MA, Zheng W, Pushkar Y,
JournalPLoS One
PubMed ID23185282
The neurotoxic effect of manganese (Mn) establishes itself in a condition known as manganism or Mn induced parkinsonism. While this condition was first diagnosed about 170 years ago, the mechanism of the neurotoxic action of Mn remains unknown. Moreover, the possibility that Mn exposure combined with other genetic and environmental ... More
Transplantation of multipotent cells extracted from adult skeletal muscles into the subventricular zone of adult rats.
AuthorsMignon L, Vourc'h P, Romero-Ramos M, Osztermann P, Young HE, Lucas PA, Chesselet MF,
JournalJ Comp Neurol
PubMed ID16127692
Stem cells isolated from adult tissues may be useful for autologous cell therapy in the nervous system. In the present study we tested the ability of multipotent stem cells isolated from adult muscle to survive and respond to migratory and differentiating cues when transplanted into the adult subventricular zone (SVZ). ... More
Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA.
AuthorsJung HJ, Coffinier C, Choe Y, Beigneux AP, Davies BS, Yang SH, Barnes RH, Hong J, Sun T, Pleasure SJ, Young SG, Fong LG,
JournalProc Natl Acad Sci U S A
PubMed ID22308344
Lamins A and C, alternatively spliced products of the LMNA gene, are key components of the nuclear lamina. The two isoforms are found in similar amounts in most tissues, but we observed an unexpected pattern of expression in the brain. Western blot and immunohistochemistry studies showed that lamin C is ... More
Aging results in copper accumulations in glial fibrillary acidic protein-positive cells in the subventricular zone.
AuthorsPushkar Y, Robison G, Sullivan B, Fu SX, Kohne M, Jiang W, Rohr S, Lai B, Marcus MA, Zakharova T, Zheng W
Journal
PubMed ID23738916
Analysis of rodent brains with X-ray fluorescence (XRF) microscopy combined with immunohistochemistry allowed us to demonstrate that local Cu concentrations are thousands of times higher in the glia of the subventricular zone (SVZ) than in other cells. Using XRF microscopy with subcellular resolution and intracellular X-ray absorption spectroscopy we determined ... More
Adult hippocampal neurogenesis inversely correlates with microglia in conditions of voluntary running and aging.
AuthorsGebara E, Sultan S, Kocher-Braissant J, Toni N
Journal
PubMed ID23970848
Adult hippocampal neurogenesis results in the formation of new neurons and is a process of brain plasticity involved in learning and memory. The proliferation of adult neural stem or progenitor cells is regulated by several extrinsic factors such as experience, disease or aging and intrinsic factors originating from the neurogenic ... More