Differential effects of prenatal and postnatal nutritional environment on ß-cell mass development and turnover in male and female rats.
AuthorsMatveyenko AV, Singh I, Shin BC, Georgia S, Devaskar SU
JournalEndocrinology
PubMed ID21047942
Fetal nutrient and growth restriction is associated with development of type 2 diabetes. Although the exact mechanisms responsible for this association remain debated, intrauterine and/or postnatal maldevelopment of ß-cell mass has been proposed as a potential mechanism. To address this hypothesis, ß-cell mass development and turnover was assessed in rats ... More