Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis.
AuthorsChang X, Yamada R, Suzuki A, Sawada T, Yoshino S, Tokuhiro S, Yamamoto K
JournalRheumatology (Oxford)
PubMed ID15466895
'Peptidylarginine deiminases (PADIs) convert peptidylarginine into citrulline via post-translational modification. Anti-citrullinated peptide antibodies are highly specific for rheumatoid arthritis (RA). Our genome-wide case-control study of single-nucleotide polymorphisms found that the PADI4 gene polymorphism is closely associated with RA. Here, we localized the expression of PADI4 and the citrullinated protein product ... More
Intravascular lymphomatosis with bone marrow involvement.
AuthorsTucker TJ, Bardales RH, Miranda RN
JournalArch Pathol Lab Med
PubMed ID10506453
We describe the case of a 56-year-old man who presented with numbness and tingling of the extremities, weakness, and fatigue. Laboratory findings included anemia and thrombocytopenia. A diagnosis of intravascular lymphomatosis was established when liver, omentum, and bone marrow samples were examined. A review of the literature reveals that most ... More
Reduced expression of activin A in focal lymphoid agglomerates within nasal polyps.
AuthorsShoham T, Yaniv E, Koren R, Gal R, Parameswaran R, Kravitz A, Geron H, Markovitz D, Lantzki M, Zipori D
JournalJ Histochem Cytochem
PubMed ID11561008
It has been previously reported that activin A, a homodimer of the betaA inhibin subunit, is secreted by stromal cells from mouse bone marrow and causes apoptotic death of mouse plasmacytoma tumor cells. Recent in vitro studies have also implicated this cytokine in the suppression of normal B-cell lymphopoiesis. In ... More