Both DNA and histone fold sequences contribute to archaeal nucleosome stability.
Authors Bailey Kathryn A; Marc Frederic; Sandman Kathleen; Reeve John N;
JournalJ Biol Chem
PubMed ID11751933
'The roles and interdependence of DNA sequence and archaeal histone fold structure in determining archaeal nucleosome stability and positioning have been determined and quantitated. The presence of four tandem copies of TTTAAAGCCG in the polylinker region of pLITMUS28 resulted in a DNA molecule with increased affinity (DeltaDeltaG of approximately 700 ... More
Escherichia coli apurinic-apyrimidinic endonucleases enhance the turnover of the adenine glycosylase MutY with G:A substrates.
Authors Pope Mary Ann; Porello Silvia L; David Sheila S;
JournalJ Biol Chem
PubMed ID11960995
The DNA repair enzyme MutY plays an important role in the prevention of DNA mutations resulting from the presence of the oxidatively damaged lesion 7,8-dihydro-8-oxo-2'-deoxyguanosine (OG). MutY is a base excision repair (BER) glycosylase that removes misincorporated adenine residues from OG:A mispairs, as well as G:A and C:A mispairs. We ... More